Institutions
The
Douville Lab Team
Our research vision
Inside
our DNA reside thousands of human endogenous retroviruses (ERVs). In certain
neurological diseases these normally dormant viruses become re-activated.
The key aim
of our research team is to delineate the relationship between ERV re-activation and the pathogenesis of ERV-associated neurological diseases. We have recently discovered a novel
ERV protein with neurotoxic potential, and we will attempt
to determine if this neurotoxic protein is associated with
neuronal damage and inflammation in the brain.
of our research team is to delineate the relationship between ERV re-activation and the pathogenesis of ERV-associated neurological diseases. We have recently discovered a novel
ERV protein with neurotoxic potential, and we will attempt
to determine if this neurotoxic protein is associated with
neuronal damage and inflammation in the brain.
© douvillelab 2013
DOUVILLE LAB
Dr. Renée N. Douville
Sheena Manghera
Matthew Turnbull
Samah Alsaadi
Heather Carr
Michael Jonasson
Sam Fineblit
Follow and support us on
Publications
1. Manghera M, Douville RN. Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors? Retrovirology. 2013 Feb 9;10:16.
PMID: 23394165
2. Olière S, Douville R, Sze A, Belgnaoui SM, Hiscott J. Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1)
pathogenesis.Cytokine Growth Factor Rev. 2011 Aug;22(4):197-210. PMID: 21924945
3. Douville R, Liu J, Rothstein J, Nath A. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral
sclerosis. Ann Neurol. 2011 Jan;69(1):141-51. PMID: 21280084
4. Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, Zhao T, Laughrea M, Wainberg MA, Hiscott J. RIG-I-mediated antiviral signaling is
inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol. 2011 Feb;85(3):1224-36. PMID: 21084468
5. Olière S, Hernandez E, Lézin A, Arguello M, Douville R, Nguyen TL, Olindo S, Panelatti G, Kazanji M, Wilkinson P, Sékaly RP, Césaire R, Hiscott J.
HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1). PLoS Pathog. 2010 Nov 4;6(11). PMID:
21079688
6. Douville RN, Lissitsyn Y, Hirschfeld AF, Becker AB, Kozyrskyj AL, Liem J, Bastien N, Li Y, Victor RE, Sekhon M, Turvey SE, HayGlass KT. TLR4
Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. PLoS One. 2010 Aug
10;5(8). PMID: 20711470
7. Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors. Cytokine. 2010 Oct-
Nov;52(1-2):108-15. PMID: 20627758
8. Stinson M, Douville R, Lissitsyn Y, Blanchard M, Stefura W, Simons E, Becker A, Nickerson P, Coombs K, HayGlass K. Quantification of human
chemokine production in TLR-stimulated and antigen-specific recall responses. Methods Mol Med. 2008;138:121-31. PMID: 18612604
9. Stefura WP, Campbell JD, Douville R, Stinson MJ, Simons FE, Becker AB, HayGlass KT. Ultrasensitive ELISA for measurement of human cytokine
responses in primary culture. Methods Mol Med. 2008;138:107-19. PMID: 18612603
10. Douville RN, Su RC, Coombs KM, Simons FE, Hayglass KT. Reovirus serotypes elicit distinctive patterns of recall immunity in humans. J Virol. 2008
Aug;82(15):7515-23. PMID: 18508904
11. Douville RN, Bastien N, Li Y, Simons FE, HayGlass KT. Adult asthmatics display exaggerated IFNgamma responses to human metapneumovirus and
respiratory syncytial virus. Biochem Cell Biol. 2007 Apr;85(2):252-8. PMID: 17534407
12. Douville RN, Bastien N, Li Y, Pochard P, Simons FE, HayGlass KT. Human metapneumovirus elicits weak IFN-gamma memory responses compared
with respiratory syncytial virus. J Immunol. 2006 May 15;176(10):5848-55. PMID: 16670291
13. Douville RN and Nath A. Endogenous Human Retroviruses and the nervous system. Neurovirology: Handbook of Clinical Neurology, 3rd series. In
Press.
PMID: 23394165
2. Olière S, Douville R, Sze A, Belgnaoui SM, Hiscott J. Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1)
pathogenesis.Cytokine Growth Factor Rev. 2011 Aug;22(4):197-210. PMID: 21924945
3. Douville R, Liu J, Rothstein J, Nath A. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral
sclerosis. Ann Neurol. 2011 Jan;69(1):141-51. PMID: 21280084
4. Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, Zhao T, Laughrea M, Wainberg MA, Hiscott J. RIG-I-mediated antiviral signaling is
inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol. 2011 Feb;85(3):1224-36. PMID: 21084468
5. Olière S, Hernandez E, Lézin A, Arguello M, Douville R, Nguyen TL, Olindo S, Panelatti G, Kazanji M, Wilkinson P, Sékaly RP, Césaire R, Hiscott J.
HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1). PLoS Pathog. 2010 Nov 4;6(11). PMID:
21079688
6. Douville RN, Lissitsyn Y, Hirschfeld AF, Becker AB, Kozyrskyj AL, Liem J, Bastien N, Li Y, Victor RE, Sekhon M, Turvey SE, HayGlass KT. TLR4
Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. PLoS One. 2010 Aug
10;5(8). PMID: 20711470
7. Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors. Cytokine. 2010 Oct-
Nov;52(1-2):108-15. PMID: 20627758
8. Stinson M, Douville R, Lissitsyn Y, Blanchard M, Stefura W, Simons E, Becker A, Nickerson P, Coombs K, HayGlass K. Quantification of human
chemokine production in TLR-stimulated and antigen-specific recall responses. Methods Mol Med. 2008;138:121-31. PMID: 18612604
9. Stefura WP, Campbell JD, Douville R, Stinson MJ, Simons FE, Becker AB, HayGlass KT. Ultrasensitive ELISA for measurement of human cytokine
responses in primary culture. Methods Mol Med. 2008;138:107-19. PMID: 18612603
10. Douville RN, Su RC, Coombs KM, Simons FE, Hayglass KT. Reovirus serotypes elicit distinctive patterns of recall immunity in humans. J Virol. 2008
Aug;82(15):7515-23. PMID: 18508904
11. Douville RN, Bastien N, Li Y, Simons FE, HayGlass KT. Adult asthmatics display exaggerated IFNgamma responses to human metapneumovirus and
respiratory syncytial virus. Biochem Cell Biol. 2007 Apr;85(2):252-8. PMID: 17534407
12. Douville RN, Bastien N, Li Y, Pochard P, Simons FE, HayGlass KT. Human metapneumovirus elicits weak IFN-gamma memory responses compared
with respiratory syncytial virus. J Immunol. 2006 May 15;176(10):5848-55. PMID: 16670291
13. Douville RN and Nath A. Endogenous Human Retroviruses and the nervous system. Neurovirology: Handbook of Clinical Neurology, 3rd series. In
Press.
Conferences
Prairie University Biology Symposium 2013. February 20th - 22nd, Regina, Saskatchewan, Canada.
Schizophrenia Society of Canada National Conference 2013. September 10th - 11th, Winnipeg, Manitoba, Canada.
Will to Win Spinal Cord Research Symposium 2013. May 13th - 14th, Winnipeg, Manitoba, Canada.
Prairie University Biology Symposium 2013. February 21st - 23rd, Winnipeg, Manitoba, Canada.
5th Annual Prairie Infectious Immunology Network Conference. September 19th - 21st, Moosejaw, Saskatchewan, Canada.
Schizophrenia Society of Canada National Conference 2013. September 10th - 11th, Winnipeg, Manitoba, Canada.
Will to Win Spinal Cord Research Symposium 2013. May 13th - 14th, Winnipeg, Manitoba, Canada.
Prairie University Biology Symposium 2013. February 21st - 23rd, Winnipeg, Manitoba, Canada.
5th Annual Prairie Infectious Immunology Network Conference. September 19th - 21st, Moosejaw, Saskatchewan, Canada.
Jennifer Ferguson
@douvillelab
Douville Lab
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